Data Entry: Please note that the research database will be replaced by UNIverse by the end of October 2023. Please enter your data into the system https://universe-intern.unibas.ch. Thanks
We evaluated the in vivo antischistosomal activities of 11 structurally diverse synthetic peroxides. Of all compounds tested, ozonide (1,2,4-trioxolane) OZ418 had the highest activity against adult Schistosoma mansoni with total and female worm burden reductions of 80 and 90% (p < 0.05). Furthermore, treatment of S. haematobium infected mice with OZ418 reduced total worm burden by 86%. In conclusion, OZ418 is a promising antischistosomal lead compound
