Antitrypanosomal sesquiterpene lactones from Saussurea costus
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 1022832
Author(s) Julianti, Tasqiah; Hata Uribe, Yoshie; Zimmermann, Stefanie; Kaiser, Marcel; Hamburger, Matthias; Adams, Michael
Author(s) at UniBasel Kaiser, Marcel
Zimmermann, Stefanie
Julianti, Tasqiah
Hata Uribe, Yoshie Adriana
Hamburger, Matthias
Adams, Michael
Year 2011
Title Antitrypanosomal sesquiterpene lactones from Saussurea costus
Journal Fitoterapia
Volume 82
Number 7
Pages / Article-Number 955-9
Keywords Saussurea costus, Asteraceae, Sesquiterpene lactones, Trypanosoma brucei rhodesiense, HPLC-based activity profiling
Abstract In the course of a larger screen of 1800 plant and fungal extracts, the ethyl acetate extract of Saussurea costus roots potently inhibited the growth of Trypanosoma brucei rhodesiense. Subsequent HPLC based activity profiling led to the identification of the sesquiterpene lactones arbusculin B (1), alpha-cyclocostunolide (2), costunolide (3), and dehydrocostuslactone (4). They were tested for in vitro antitrypanosomal activities and cytotoxicity alongside the structurally related sesquiterpene lactones parthenolide (5), zaluzanin D (6), and eupatoriopicrin (7), and had IC(50)s between 0.8 and 22muM. Cytotoxic IC(50)s were from 1.6 to 19muM, and selectivity indices from 0.5 to 6.5
Publisher Elsevier Science
ISSN/ISBN 0367-326X
edoc-URL http://edoc.unibas.ch/dok/A6002118
Full Text on edoc No
Digital Object Identifier DOI 10.1016/j.fitote.2011.05.010
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/21624443
ISI-Number WOS:000295442800004
Document type (ISI) Journal Article
 
   

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