Antiprotozoal activity of Melampyrum arvense and its metabolites
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
ID 1022828
Author(s) Kirmizibekmez, Hasan; Atay, Irem; Kaiser, Marcel; Brun, Reto; Cartagena, Michelle M; Carballeira, Néstor M; Yesilada, Erdem; Tasdemir, Deniz
Author(s) at UniBasel Kaiser, Marcel
Brun, Reto
Year 2011
Title Antiprotozoal activity of Melampyrum arvense and its metabolites
Journal Phytotherapy research : an international journal devoted to pharmacological and toxocological evaluation of natural product derivatives
Volume 25
Number 1
Pages / Article-Number 142-6
Keywords Melampyrum arvense, iridoid glucosides, flavonoids, Trypanosoma, Leishmania, Plasmodium
Abstract An activity guided isolation of the H(2)O subextract of the crude extract of Melampyrum arvense L. afforded iridoid glucosides: aucubin (1), melampyroside (2), mussaenoside (3), mussaenosidic acid (4), 8-epi-loganin (5); flavonoids: apigenin (6), luteolin (7), luteolin 7-O-beta-glucopyranoside (8); a lignan glycoside dehydrodiconiferyl alcohol 9-O-beta-glucopyranoside (9); and benzoic acid (10). beta-Sitosterol (11) and a fatty acid mixture (12) were identified as the active principles of the CHCl(3) subextract. The structures of the isolates were elucidated by spectroscopic methods, while the composition of 12 was identified by GC-MS after methylation. Luteolin (7) appeared as the most active compound against Trypanosoma brucei rhodesiense and Leishmania donovani (IC(50) values 3.8 and 3.0 mug/mL). Luteolin 7-O-beta-glucopyranoside (8) displayed the best antiplasmodial activity against Plasmodium falciparum (IC(50) value 2.9 mug/mL). This is the first detailed phytochemical study on Turkish M. arvense and the first report of the antiprotozoal effect of Melampyrum species and its constituents. Copyright (c) 2010 John Wiley & Sons, Ltd
Publisher John Wiley
ISSN/ISBN 1099-1573
Full Text on edoc No
Digital Object Identifier DOI 10.1002/ptr.3233
PubMed ID
ISI-Number WOS:000285848700022
Document type (ISI) Journal Article

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