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Anti-inflammatory and antimalarial meroterpenoids from the New Zealand ascidian Aplidium scabellum
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
ID
1022821
Author(s)
Chan, Susanna T S; Pearce, A Norrie; Januario, Ana H; Page, Michael J; Kaiser, Marcel; McLaughlin, Rene J; Harper, Jacquie L; Webb, Victoria L; Barker, David; Copp, Brent R
Anti-inflammatory and antimalarial meroterpenoids from the New Zealand ascidian Aplidium scabellum
Journal
The journal of organic chemistry
Volume
76
Number
21
Pages / Article-Number
9151-6
Abstract
Bioassay-directed fractionation of an extract of the New Zealand ascidian Aplidium scabellum has afforded the anti-inflammatory secondary metabolite 2-geranyl-6-methoxy-1,4-hydroquinone-4-sulfate (1) and a family of pseudodimeric meroterpenoids scabellones A (2)-D (5). The benzo[c]chromene-7,10-dione scaffold contained within scabellones A-D is particularly rare among natural products. The structures were elucidated by interpretation of NMR data. Scabellone B was also identified as a moderately potent, nontoxic inhibitor of Plasmodium falciparum
