Anti-inflammatory and antimalarial meroterpenoids from the New Zealand ascidian Aplidium scabellum
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 1022821
Author(s) Chan, Susanna T S; Pearce, A Norrie; Januario, Ana H; Page, Michael J; Kaiser, Marcel; McLaughlin, Rene J; Harper, Jacquie L; Webb, Victoria L; Barker, David; Copp, Brent R
Author(s) at UniBasel Kaiser, Marcel
Year 2011
Title Anti-inflammatory and antimalarial meroterpenoids from the New Zealand ascidian Aplidium scabellum
Journal The journal of organic chemistry
Volume 76
Number 21
Pages / Article-Number 9151-6
Abstract Bioassay-directed fractionation of an extract of the New Zealand ascidian Aplidium scabellum has afforded the anti-inflammatory secondary metabolite 2-geranyl-6-methoxy-1,4-hydroquinone-4-sulfate (1) and a family of pseudodimeric meroterpenoids scabellones A (2)-D (5). The benzo[c]chromene-7,10-dione scaffold contained within scabellones A-D is particularly rare among natural products. The structures were elucidated by interpretation of NMR data. Scabellone B was also identified as a moderately potent, nontoxic inhibitor of Plasmodium falciparum
Publisher American Chemical Society
ISSN/ISBN 0022-3263
edoc-URL http://edoc.unibas.ch/dok/A6002108
Full Text on edoc No
Digital Object Identifier DOI 10.1021/jo201654h
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/21958335
ISI-Number WOS:000296206400061
Document type (ISI) Journal Article
 
   

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