A role for systems epidemiology in tuberculosis research
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
ID 1022806
Author(s) Comas, Iñaki; Gagneux, Sebastien
Author(s) at UniBasel Gagneux, Sebastien
Year 2011
Title A role for systems epidemiology in tuberculosis research
Journal Trends in microbiology : virulence, infection and pathogenesis
Volume 19
Number 10
Pages / Article-Number 492-500
Abstract Despite being a curable disease, tuberculosis (TB) killed more people in 2009 than during any previous year in history. Progress in TB research has been slow, and remains burdened by important gaps in our knowledge of the basic biology of Mycobacterium tuberculosis, the causative agent of TB, and its interaction with the human host. Fortunately, major systems biology initiatives have recently been launched that will help fill some of these gaps. However, to fully comprehend TB and control this disease globally, current systems biological approaches will not suffice. The influence of host and pathogen diversity, changes in human demography, and socioeconomic and environmental factors will also need to be considered. Such a multidisciplinary approach might be best described as 'systems epidemiology' in an effort to overcome the traditional boundaries between basic biology and classical epidemiology
Publisher Elsevier
ISSN/ISBN 0966-842X
edoc-URL http://edoc.unibas.ch/dok/A6002094
Full Text on edoc No
Digital Object Identifier DOI 10.1016/j.tim.2011.07.002
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/21831640
ISI-Number WOS:000296002300004
Document type (ISI) Journal Article, Review

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