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Diastereoselective and Highly Enantioselective Henry Reactions using C(1)-Symmetrical Copper(II) Complexes
Journal
Advanced Synthesis and Catalysis
Volume
353
Number
10
Pages / Article-Number
1797-1806
Keywords
copper(II) complexes, diastereoselectivity, enantioselectivity, Henry reaction, nitroaldol reaction
Abstract
Catalytic Henry reactions of aliphatic aldehydes and prochiral nitro compounds were investigated using copper(II) complexes of 14 C(1)-symmetrical ligands derived from (1R,2R)(-)-diaminocyclohexane. beta-Nitro alcohols with syn:anti ratios of up to 5.7 and excellent ee values for both diastereosimers were obtained.
