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Surfactants of natural origin for the formulation and delivery of poorly water soluble drugs
Project funded by own resources |
Project title |
Surfactants of natural origin for the formulation and delivery of poorly water soluble drugs |
Principal Investigator(s) |
Hamburger, Matthias Imanidis, Georgios
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Organisation / Research unit |
Departement Pharmazeutische Wissenschaften / Pharmazeutische Biologie (Hamburger) |
Project start |
01.01.2011 |
Probable end |
31.12.2012 |
Status |
Completed |
Abstract |
Plants produce various primary and secondary metabolites whith amphiphilic properties, such as phospholipids and saponins. Crude fractions/extracts containing such compounds are used extensively in food technology. However, the potential of natural surfactants in drug formulation is not exploited.
The project explores the potential of purified and defined mixtures of saponins derived from Quillaia saponaria, a food grade saponin source, for the formulation and delivery of poorly soluble drug substances. The saponins are characterized by HPLC and spectroscopic methods, and key physicochemical properties are determined to guide formulation studies. Lipid-based formulations are then developed on the basis of microemulsions, self emulsifying systems, and micellar acqueous systems. |
Keywords |
Saponin, surfactant, formulation science |
Financed by |
Other funds
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Cooperations () |
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ID |
Kreditinhaber |
Kooperationspartner |
Institution |
Laufzeit - von |
Laufzeit - bis |
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169724 |
Hamburger, Matthias |
Imanidis Georgios |
FHNW |
01.01.2011 |
31.12.2012 |
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29/03/2024
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