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Surfactants of natural origin for the formulation and delivery of poorly water soluble drugs
Project funded by own resources
Project title Surfactants of natural origin for the formulation and delivery of poorly water soluble drugs
Principal Investigator(s) Hamburger, Matthias
Imanidis, Georgios
Organisation / Research unit Departement Pharmazeutische Wissenschaften / Pharmazeutische Biologie (Hamburger)
Project start 01.01.2011
Probable end 31.12.2012
Status Completed
Abstract

Plants produce various primary and secondary metabolites whith amphiphilic properties, such as phospholipids and saponins. Crude fractions/extracts containing such compounds are used extensively in food technology. However, the potential of natural surfactants in drug formulation is not exploited.

The project explores the potential of purified and defined mixtures of saponins derived from Quillaia saponaria, a food grade saponin source, for the formulation and delivery of poorly soluble drug substances. The saponins are characterized by HPLC and spectroscopic methods, and key physicochemical properties are determined to guide formulation studies. Lipid-based formulations are then developed on the basis of microemulsions, self emulsifying systems, and micellar acqueous systems.

Keywords Saponin, surfactant, formulation science
Financed by Other funds

Cooperations ()

  ID Kreditinhaber Kooperationspartner Institution Laufzeit - von Laufzeit - bis
169724  Hamburger, Matthias  Imanidis Georgios  FHNW  01.01.2011  31.12.2012 
   

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