An Artificial Metalloenzyme for Olefin Metathesis
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 1014781
Author(s) Clemens, M.; Gillingham, Dennis; Ward, Thomas R.; Hilvert, Donald
Author(s) at UniBasel Ward, Thomas R.
Gillingham, Dennis
Year 2011
Title An Artificial Metalloenzyme for Olefin Metathesis
Journal Journal of the Chemical Society, Chemical Communications
Volume 47
Number 44
Pages / Article-Number 12068-12070
Keywords HEAT-SHOCK-PROTEIN; METHANOCOCCUS-JANNASCHII; CROSS-METATHESIS; CATALYSTS; WATER; SITE
Abstract A Grubbs-Hoveyda type olefin metathesis catalyst, equipped with an electrophilic bromoacetamide group, was used to modify a cysteine-containing variant of a small heat shock protein from Methanocaldococcus jannaschii. The resulting artificial metalloenzyme was found to be active under acidic conditions in a benchmark ring closing metathesis reaction.
Publisher Royal Society of Chemistry
ISSN/ISBN 0022-4936
edoc-URL http://edoc.unibas.ch/dok/A6002023
Full Text on edoc No
Digital Object Identifier DOI 10.1039/c1cc15005g
ISI-Number 000296342800007
Document type (ISI) Article
 
   

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