Artificial Transfer Hydrogenases for the Enantioselective Reduction of Cyclic Imines
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 1014706
Author(s) Dürrenberger, Marc; Heinisch, Tillmann; Wilson, Yvonne; Rossel, Thibaud; Nogueira, Elisa; Knörr, Livia; Mutschler, Annette; Kersten, Karoline; Zimbron, Mallcom; Pierron, Julien; Schirmer, Tilman; Ward, Thomas R.
Author(s) at UniBasel Ward, Thomas R.
Dürrenberger, Marc
Wilson, Yvonne Martha
Rossel, Thibaud
Nogueira, Elisa
Knörr, Livia
Heinisch, Tillmann
Dürrenberger, Markus
Schirmer, Tilman
Year 2011
Title Artificial Transfer Hydrogenases for the Enantioselective Reduction of Cyclic Imines
Journal Angewandte Chemie International Edition
Volume 50
Number 13
Pages / Article-Number 3026-9
Keywords artificial metalloenzymes, asymmetric catalysis, imine reduction, piano stool complexes, transfer hydrogenation
Abstract Man-made activity: Introduction of a biotinylated iridium piano stool complex within streptavidin affords an artificial imine reductase (see scheme). Saturation mutagenesis allowed optimization of the activity and the enantioselectivity of this metalloenzyme, and its X-ray structure suggests that a nearby lysine residue acts as a proton source during the transfer hydrogenation.
Publisher Wiley
ISSN/ISBN 1433-7851 ; 1521-3773
edoc-URL http://edoc.unibas.ch/dok/A6002018
Full Text on edoc No
Digital Object Identifier DOI 10.1002/anie.201007820
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/21404391
ISI-Number 000288333600027
Document type (ISI) Journal Article
 
   

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