Artificial Transfer Hydrogenases for the Enantioselective Reduction of Cyclic Imines
Angewandte Chemie International Edition
Pages / Article-Number
artificial metalloenzymes, asymmetric catalysis, imine reduction, piano stool complexes, transfer hydrogenation
Man-made activity: Introduction of a biotinylated iridium piano stool complex within streptavidin affords an artificial imine reductase (see scheme). Saturation mutagenesis allowed optimization of the activity and the enantioselectivity of this metalloenzyme, and its X-ray structure suggests that a nearby lysine residue acts as a proton source during the transfer hydrogenation.