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A Unified Approach for the Stereoselective Total Synthesis of Pyridone Alkaloids and Their Neuritogenic Activity
Journal
Angewandte Chemie International Edition
Volume
50
Number
18
Pages / Article-Number
4222-4226
Keywords
farinosone A, militarinone D, neurite outgrowth, neurochemistry, pyridone alkaloids
Abstract
Unus pro omnibus: The development of compounds inducing neurite outgrowth might constitute a valuable approach for the non-invasive medical treatment of neurodegenerative diseases. With the aid of a bifunctional building block, the total syntheses of a group of pyridone polyenes originally produced by entomopathogenic fungi was achieved (see picture). All of these natural products displayed neuritogenic activity in the PC-12 cell line.