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A Unified Approach for the Stereoselective Total Synthesis of Pyridone Alkaloids and Their Neuritogenic Activity
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 1008035
Author(s) Schumacher, Andreas; Jessen, Henning J.; Shaw, Trawis; Pfaltz, Andreas; Gademann, Karl
Author(s) at UniBasel Gademann, Karl
Pfaltz, Andreas
Year 2011
Title A Unified Approach for the Stereoselective Total Synthesis of Pyridone Alkaloids and Their Neuritogenic Activity
Journal Angewandte Chemie International Edition
Volume 50
Number 18
Pages / Article-Number 4222-4226
Keywords farinosone A, militarinone D, neurite outgrowth, neurochemistry, pyridone alkaloids
Abstract Unus pro omnibus: The development of compounds inducing neurite outgrowth might constitute a valuable approach for the non-invasive medical treatment of neurodegenerative diseases. With the aid of a bifunctional building block, the total syntheses of a group of pyridone polyenes originally produced by entomopathogenic fungi was achieved (see picture). All of these natural products displayed neuritogenic activity in the PC-12 cell line.
Publisher Wiley
ISSN/ISBN 1433-7851 ; 1521-3773
edoc-URL http://edoc.unibas.ch/dok/A5849081
Full Text on edoc No
Digital Object Identifier DOI 10.1002/anie.201007671
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/21448865
ISI-Number WOS:000290662500036
Document type (ISI) Article
 
   

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29/03/2024