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Integrated epigenetics of human breast cancer : synoptic investigation of targeted genes, microRNAs and proteins upon demethylation treatment
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 1004331
Author(s) Radpour, R.; Barekati, Z.; Kohler, C.; Schumacher, M. M.; Grussenmeyer, T.; Jenoe, P.; Hartmann, N.; Moes, S.; Letzkus, M.; Bitzer, J.; Lefkovits, I.; Staedtler, F.; Zhong, X. Y.
Author(s) at UniBasel Jenö, Paul
Moes, Suzanne
Bitzer, Johannes
Zhong, Xiao Yan
Year 2011
Title Integrated epigenetics of human breast cancer : synoptic investigation of targeted genes, microRNAs and proteins upon demethylation treatment
Journal PLoS ONE
Volume 6
Number 11
Pages / Article-Number e27355
Mesh terms Antimetabolites, Antineoplastic, pharmacology; Apoptosis; Azacitidine, pharmacology; Biomarkers, Tumor, metabolism; Blotting, Western; Breast Neoplasms, metabolism; Cell Line, Tumor; Cell Proliferation; DNA Methylation; Electrophoresis, Gel, Two-Dimensional; Epigenesis, Genetic; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; MicroRNAs, physiology; Oligonucleotide Array Sequence Analysis; Promoter Regions, Genetic, genetics; RNA, Messenger, genetics; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Abstract The contribution of aberrant DNA methylation in silencing of tumor suppressor genes (TSGs) and microRNAs has been investigated. Since these epigenetic alterations are reversible, it became of interest to determine the effects of the 5-aza-2'-deoxycytidine (DAC) demethylation therapy in breast cancer at different molecular levels.
Publisher Public Library of Science
ISSN/ISBN 1932-6203
edoc-URL http://edoc.unibas.ch/dok/A6004703
Full Text on edoc No
Digital Object Identifier DOI 10.1371/journal.pone.0027355
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/22076154
ISI-Number WOS:000297198200068
Document type (ISI) Journal Article
 
   

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