Treating treatment non-responders: A meta-analysis of randomized controlled psychotherapy trials

Research Database / FORSCHUNGSDATENBANK

Publication 4597431 | Verified

Data Entry: Please note that the research database will be replaced by UNIverse by the end of October 2023. Please enter your data into the system https://universe-intern.unibas.ch. Thanks

Login for users with Unibas email account...

Login for registered users without Unibas email account...

Treating treatment non-responders: A meta-analysis of randomized controlled psychotherapy trials

JournalItem (Reviews, Editorials, Rezensionen, Urteilsanmerkungen etc. in einer wissenschaftlichen Zeitschrift)

4597431

Author(s)

Gloster, Andrew T.; Rinner, Marcia T. B.; Ioannou, Myria; Villanueva, Jeanette; Block, Victoria J.; Ferrari, Giovanna; Benoy, Charles; Bader, Klaus; Karekla, Maria

Author(s) at UniBasel

Gloster, Andrew

Year

2020

Title

Treating treatment non-responders: A meta-analysis of randomized controlled psychotherapy trials

Journal

Clinical Psychology Review

Volume

Pages

101810

Keywords

Meta-analysis; Anxiety; Psychotherapy; Depression; Treatment-resistant; Nonresponse

Mesh terms

Social SciencesPsychology, ClinicalPsychology

Abstract

Background: Non-responsiveness to treatment occurs in approximately one third of patients. Randomized clinical trials of psychotherapy options for these patients are scarce and systematic knowledge about whether psychotherapy is a viable option is lacking.Objectives: This meta-analysis aimed to 1) determine the amount of evidence available for treatment non-response using psychotherapy relative to pharmacological procedures; 2) systematically review randomized controlled psychotherapy trials (RCTs) used to treat non-responders; and 3) examine whether some psychotherapies are more efficacious than others.Data sources: Online databases were systematically examined and references of relevant systematic reviews were hand-searched.Study eligibility criteria: RCTs that administered a psychotherapy new to non-responders were considered. All Mood and Anxiety Disorders were considered. No limitations were made with respect to type of treatment.Review method: A meta-analytic review of the psychotherapy RCTs for treatment non-responders.Results: Results showed that psychotherapy was successful in treating treatment non-responders with a medium to large effect size. Between-group comparisons did not reveal significant differences in treatment effects for any of the assessed disorder or treatment types. Effects were maintained at follow-up.Conclusions: Psychotherapy is a viable treatment option for treatment non-responders. More attention to this group of patients is needed and more research with better quality studies is warranted. Recommendations are discussed.

Publisher

Elsevier

ISSN/ISBN

0272-7358

edoc-URL

https://edoc.unibas.ch/76569/

Full Text on edoc

Available

Digital Object Identifier DOI

10.1016/j.cpr.2019.101810

PubMed ID

http://www.ncbi.nlm.nih.gov/pubmed/31884147