Publications
Showing records 1 - 20 (of 48)
Publication: JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
ID
Author
Year
Title
Publisher
4700014 Colina-Vegas, L.; da Cruz, B. Silva M.; de Souza Pereira, C.; Isis Barros, A.; Araújo Nobrega, J.; Navarro, M.; Rottmann, M.; D'Alessandro, S.; Basilico, N.; Azevedo Batista, A.; Moreira, D. R. M.
2023
Antimalarial agents derived from metal-amodiaquine complexes with activity in multiple stages of the plasmodium life cycle
Chemistry
4651659 Khandelwal, A.; Arez, F.; Alves, P. M.; Badolo, L.; Brito, C.; Fischli, C.; Fontinha, D.; Oeuvray, C.; Prudêncio, M.; Rottmann, M.; Wilkins, J.; Yalkinoglu, Ö.; Bagchus, W. M.; Spangenberg, T.
2022
Translation of liver stage activity of M5717, a; Plasmodium; elongation factor 2 inhibitor: from bench to bedside
Malar J
4651617 Hirsch, A. K. H.; Diamanti, E.; Hamed, M. M.; Lacour, A.; Bravo, P.; Illarionov, B.; Fischer, M.; Rottmann, M.; Witschel, M.
2022
Targeting the IspD enzyme in the MEP pathway: identification of a novel fragment class
ChemMedChem
4651699 Lowe, M. A.; Cardenas, A.; Valentin, J. P.; Zhu, Z.; Abendroth, J.; Castro, J. L.; Class, R.; Delaunois, A.; Fleurance, R.; Gerets, H.; Gryshkova, V.; King, L.; Lorimer, D. D.; MacCoss, M.; Rowley, J. H.; Rosseels, M. L.; Royer, L.; Taylor, R. D.; Wong, M.; Zaccheo, O.; Chavan, V. P.; Ghule, G. A.; Tapkir, B. K.; Burrows, J. N.; Duffey, M.; Rottmann, M.; Wittlin, S.; Angulo-Barturen, I.; Jiménez-Díaz, M. B.; Striepen, J.; Fairhurst, K. J.; Yeo, T.; Fidock, D. A.; Cowman, A. F.; Favuzza, P.; Crespo-Fernandez, B.; Gamo, F. J.; Goldberg, D. E.; Soldati-Favre, D.; Laleu, B.; de Haro, T.
2022
Discovery and characterization of potent, efficacious, orally available antimalarial plasmepsin X inhibitors and preclinical safety assessment of UCB7362
Journal of medicinal chemistry
4651912 Wicha, S. G.; Walz, A.; Cherkaoui-Rbati, M. H.; Bundgaard, N.; Kuritz, K.; Gumpp, C.; Gobeau, N.; Möhrle, J.; Rottmann, M.; Demarta-Gatsi, C.
2022
New in vitro interaction-parasite reduction ratio assay for early derisk in clinical development of antimalarial combinations
Antimicrob Agents Chemother
4651806 Radohery, G. F. R.; Walz, A.; Gumpp, C.; Cherkaoui-Rbati, M. H.; Gobeau, N.; Gower, J.; Davenport, M. P.; Rottmann, M.; McCarthy, J. S.; Möhrle, J. J.; Rebelo, M.; Demarta-Gatsi, C.; Khoury, D. S.
2022
Parasite viability as a measure of in vivo drug activity in preclinical and early clinical antimalarial drug assessment
Antimicrob Agents Chemother
4646141 Ropponen, H. K.; Diamanti, E.; Siemens, A.; Illarionov, B.; Haupenthal, J.; Fischer, M.; Rottmann, M.; Witschel, M.; Hirsch, A. K. H.
2021
Assessment of the rules related to gaining activity against gram-negative bacteria
RSC Med Chem
4597080 Mueller, Rudolf; Reddy, Virsinha; Nchinda, Aloysius T.; Mebrahtu, Fanuel; Taylor, Dale; Lawrence, Nina; Tanner, Lloyd; Barnabe, Marine; Eyermann, Charles J.; Zou, Bin; Kondreddi, Ravinder R.; Lakshminarayana, Suresh B.; Rottmann, Matthias; Street, Leslie J.; Chibale, Kelly
2020
Lerisetron analogues with antimalarial properties: synthesis, structure-activity relationship studies, and biological assessment
ACS Omega
4596449 Rottmann, Matthias; Jonat, Brian; Gumpp, Christin; Dhingra, Satish K.; Giddins, Marla J.; Yin, Xiaoyan; Badolo, Lassina; Greco, Beatrice; Fidock, David A.; Oeuvray, Claude; Spangenberg, Thomas
2020
Preclinical antimalarial combination studies: the case of M5717, a P. falciparum elongation factor 2 inhibitor and pyronaridine, a hemozoin formation inhibitor
Antimicrobial agents and chemotherapy
4597088 Favuzza, Paola; de Lera Ruiz, Manuel; Thompson, Jennifer K.; Triglia, Tony; Ngo, Anna; Steel, Ryan W. J.; Vavrek, Marissa; Christensen, Janni; Healer, Julie; Boyce, Christopher; Guo, Zhuyan; Hu, Mengwei; Khan, Tanweer; Murgolo, Nicholas; Zhao, Lianyun; Penington, Jocelyn Sietsma; Reaksudsan, Kitsanapong; Jarman, Kate; Dietrich, Melanie H.; Richardson, Lachlan; Guo, Kai-Yuan; Lopaticki, Sash; Tham, Wai-Hong; Rottmann, Matthias; Papenfuss, Tony; Robbins, Jonathan A.; Boddey, Justin A.; Sleebs, Brad E.; Sabroux, Hélène Jousset; McCauley, John A.; Olsen, David B.; Cowman, Alan F.
2020
Dual plasmepsin-targeting antimalarial agents disrupt multiple stages of the malaria parasite life cycle
Cell host & microbe
4596372 Burgert, Lydia; Rottmann, Matthias; Wittlin, Sergio; Gobeau, Nathalie; Krause, Andreas; Dingemanse, Jasper; Möhrle, Jörg J.; Penny, Melissa A.
2020
Ensemble modeling highlights importance of understanding parasite-host behavior in preclinical antimalarial drug development
Scientific reports
4501060 Baragaña, Beatriz; Forte, Barbara; Choi, Ryan; Nakazawa Hewitt, Stephen; Bueren-Calabuig, Juan A.; Pisco, João Pedro; Peet, Caroline; Dranow, David M.; Robinson, David A.; Jansen, Chimed; Norcross, Neil R.; Vinayak, Sumiti; Anderson, Mark; Brooks, Carrie F.; Cooper, Caitlin A.; Damerow, Sebastian; Delves, Michael; Dowers, Karen; Duffy, James; Edwards, Thomas E.; Hallyburton, Irene; Horst, Benjamin G.; Hulverson, Matthew A.; Ferguson, Liam; Jiménez-Díaz, María Belén; Jumani, Rajiv S.; Lorimer, Donald D.; Love, Melissa S.; Maher, Steven; Matthews, Holly; McNamara, Case W.; Miller, Peter; O'Neill, Sandra; Ojo, Kayode K.; Osuna-Cabello, Maria; Pinto, Erika; Post, John; Riley, Jennifer; Rottmann, Matthias; Sanz, Laura M.; Scullion, Paul; Sharma, Arvind; Shepherd, Sharon M.; Shishikura, Yoko; Simeons, Frederick R. C.; Stebbins, Erin E.; Stojanovski, Laste; Straschil, Ursula; Tamaki, Fabio K.; Tamjar, Jevgenia; Torrie, Leah S.; Vantaux, Amélie; Witkowski, Benoît; Wittlin, Sergio; Yogavel, Manickam; Zuccotto, Fabio; Angulo-Barturen, Iñigo; Sinden, Robert; Baum, Jake; Gamo, Francisco-Javier; Mäser, Pascal; Kyle, Dennis E.; Winzeler, Elizabeth A.; Myler, Peter J.; Wyatt, Paul G.; Floyd, David; Matthews, David; Sharma, Amit; Striepen, Boris; Huston, Christopher D.; Gray, David W.; Fairlamb, Alan H.; Pisliakov, Andrei V.; Walpole, Chris; Read, Kevin D.; Van Voorhis, Wesley C.; Gilbert, Ian H.
2019
Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis
Proceedings of the National Academy of Sciences of the United States of America
4516381 Arez, Francisca; Rebelo, Sofia P.; Fontinha, Diana; Simão, Daniel; Martins, Tatiana R.; Machado, Marta; Fischli, Christoph; Oeuvray, Claude; Badolo, Lassina; Carrondo, Manuel J. T.; Rottmann, Matthias; Spangenberg, Thomas; Brito, Catarina; Greco, Beatrice; Prudêncio, Miguel; Alves, Paula M.
2019
Flexible 3D cell-based platforms for the discovery and profiling of novel drugs targeting plasmodium hepatic infection
ACS infectious diseases
4487813 Martí Coma-Cros, Elisabet; Biosca, Arnau; Marques, Joana; Carol, Laura; Urbán, Patricia; Berenguer, Diana; Riera, Maria Cristina; Delves, Michael; Sinden, Robert E.; Valle-Delgado, Juan José; Spanos, Lefteris; Siden-Kiamos, Inga; Pérez, Paula; Paaijmans, Krijn; Rottmann, Matthias; Manfredi, Amedea; Ferruti, Paolo; Ranucci, Elisabetta; Fernàndez-Busquets, Xavier
2018
Polyamidoamine nanoparticles for the oral administration of antimalarial drugs
Pharmaceutics
4487277 Grogg, Marcel; Hilvert, Donald; Ebert, Marc-Olivier; Beck, Albert K.; Seebach, Dieter; Kurth, Felix; Dittrich, Petra S.; Sparr, Christof; Wittlin, Sergio; Rottmann, Matthias; Mäser, Pascal
2018
Cell penetration, herbicidal activity, and in-vivo-toxicity of oligo-arginine derivatives and of novel guanidinium-rich compounds derived from the biopolymer cyanophycin
Helvetica Chimica Acta
4325865 Levatić, Jurica; Pavić, Kristina; Perković, Ivana; Uzelac, Lidija; Ester, Katja; Kralj, Marijeta; Kaiser, Marcel; Rottmann, Matthias; Supek, Fran; Zorc, Branka
2018
Machine learning prioritizes synthesis of primaquine ureidoamides with high antimalarial activity and attenuated cytotoxicity
European journal of medicinal chemistry
4481974 Schwertz, Geoffrey; Witschel, Matthias C.; Rottmann, Matthias; Leartsakulpanich, Ubolsree; Chitnumsub, Penchit; Jaruwat, Aritsara; Amornwatcharapong, Watcharee; Ittarat, Wanwipa; Schäfer, Anja; Aponte, Raphael A.; Trapp, Nils; Chaiyen, Pimchai; Diederich, François
2018
Potent inhibitors of plasmodial serine hydroxymethyltransferase (SHMT) featuring a spirocyclic scaffold
ChemMedChem
4102915 Schwertz, Geoffrey; Frei, Michelle S.; Witschel, Matthias C.; Rottmann, Matthias; Leartsakulpanich, Ubolsree; Chitnumsub, Penchit; Jaruwat, Aritsara; Ittarat, Wanwipa; Schäfer, Anja; Aponte, Raphael A.; Trapp, Nils; Mark, Kerstin; Chaiyen, Pimchai; Diederich, François
2017
Conformational aspects in the design of inhibitors for serine hydroxymethyltransferase (SHMT): biphenyl, aryl sulfonamide, and aryl sulfone motifs
Chemistry - A European Journal
3870589 Schwertz, Geoffrey; Witschel, Matthias C.; Rottmann, Matthias; Bonnert, Roger; Leartsakulpanich, Ubolsree; Chitnumsub, Penchit; Jaruwat, Aritsara; Ittarat, Wanwipa; Schäfer, Anja; Aponte, Raphael A.; Charman, Susan A.; White, Karen L.; Kundu, Abhijit; Sadhukhan, Surajit; Lloyd, Mel; Freiberg, Gail M.; Srikumaran, Myron; Siggel, Marc; Zwyssig, Adrian; Chaiyen, Pimchai; Diederich, François
2017
Antimalarial inhibitors rargeting serine hydroxymethyltransferase (SHMT) with in vivo efficacy and analysis of their binding mode based on X-ray cocrystal structures
Journal of Medicinal Chemistry
3611822 Najer, Adrian; Wu, Dalin; Nussbaumer, Martin G.; Schwertz, Geoffrey; Schwab, Anatol; Witschel, Matthias C.; Schafer, Anja; Diederich, Francois; Rottmann, Matthias; Palivan, Cornelia G.; Beck, Hans-Peter; Meier, Wolfgang
2016
An amphiphilic graft copolymer-based nanoparticle platform for reduction-responsive anticancer and antimalarial drug delivery
Nanoscale
Showing records 1 - 20 (of 48)
