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Extended steroid profiling in H295R cells provides deeper insight into chemical-induced disturbances of steroidogenesis: Exemplified by prochloraz and anabolic steroids.
Salt-Sensitive Hypertension in GR; +/-; Rats Is Accompanied with Dysregulation in Adrenal Soluble Epoxide Hydrolase and Polyunsaturated Fatty Acid Pathways.
Deletion of the transcription factor Prox-1 specifically in the renal distal convoluted tubule causes hypomagnesemia via reduced expression of TRPM6 and NCC
In vitro models to study insulin and glucocorticoids modulation of trimethyltin (TMT)-induced neuroinflammation and neurodegeneration, and in vivo validation in db/db mice
Identification of the fungicide epoxiconazole by virtual screening and biological assessment as inhibitor of human 11β-hydroxylase and aldosterone synthase
Journal of Steroid Biochemistry and Molecular Biology
Beck, Katharina R.; Kanagaratnam, Sharavan; Kratschmar, Denise V.; Birk, Julia; Yamaguchi, Hideaki; Sailer, Andreas W.; Seuwen, Klaus; Odermatt, Alex
2019
Enzymatic interconversion of the oxysterols 7β,25-dihydroxycholesterol and 7-keto,25-hydroxycholesterol by 11β-hydroxysteroid dehydrogenase type 1 and 2
The Journal of steroid biochemistry and molecular biology
Strajhar, Petra; Vizeli, Patrick; Patt, Melanie; Dolder, Patrick C.; Kratschmar, Denise V.; Liechti, Matthias E.; Odermatt, Alex
2019
Effects of lisdexamfetamine on plasma steroid concentrations compared with d-amphetamine in healthy subjects: A randomized, double-blind, placebo-controlled study
Journal of Steroid Biochemistry and Molecular Biology
Absence of hexose-6-phosphate dehydrogenase results in reduced overall glucose consumption but does not prevent 11β-hydroxysteroid dehydrogenase-1-dependent glucocorticoid activation
Boudon, Stéphanie M.; Vuorinen, Anna; Geotti-Bianchini, Piero; Wandeler, Eliane; Kratschmar, Denise V.; Heidl, Marc; Campiche, Remo; Jackson, Eileen; Odermatt, Alex
2017
Novel 11β-hydroxysteroid dehydrogenase 1 inhibitors reduce cortisol levels in keratinocytes and improve dermal collagen content in human ex vivo skin after exposure to cortisone and UV